In a special episode of Strong Medicine, the Rittenhouse Hospital Emergency Medical Services team is introduced. EMTs Kate and Zach are attacked while trying to save a young girl's life, figure out the motive behind it, and reach a dubious resolution. Then, a multiple vehicle accident keeps them and Dr. Vanessa Burke, an African American trauma surgeon and Katie's adoptive sister, busy. A chemical spill threatens the lives of those in the accident and a guilty driver makes an impulsive decision. Meanwhile, a pre-teen in the accident needs a transplant and Katie and Lu search homeless shelters for a match. Even after they find one, they still face some difficulties. Vanessa amputates the legs of a man who begged her to let him die and must convince him that life without legs is still worth living.