Lola is excited about the possiblity of caring after her class's pet guinea pig, Burt. Her classmates, however, seem to know more about guinea pigs than her, so she is delighted when she is, indeed, picked. Lola does her best to take care of Burt, learning many things she needs to know from Mrs. Hanson and learning others from her classmates. Lola sets up a guinea pig run for Burt, but then Burt escapes. That's when Lola and Charlie discover a surprising fact about Burt.